Severe leukopenia and thrombocytopenia secondary to quinidine
نویسندگان
چکیده
منابع مشابه
Quinidine-induced thrombocytopenia and leukopenia: demonstration and characterization of distinct antiplatelet and antileukocyte antibodies.
A patient with the rare syndrome of simultaneous quinidine-induced thrombocytopenia and leukopenia was studied. A quinidine-dependent antiplatelet antibody was detected in her serum by platelet aggregometry and by indirect platelet-suspension immunofluorescence. A drug-dependent antileukocyte antibody was demonstrated by leukoagglutination and by granulocyte immunofluorescence. Both antibodies ...
متن کاملQuinidine - Induced Thrombocytopenia and Leukopenia : Demonstration and Characterization of Distinct Antiplatelet
A patient with the rare syndrome of simultaneous quinidine-induced thrombocytopenia and leukopenia was studied. A quinidine-dependent antiplatelet antibody was detected in her serum by platelet aggregometry and by indirect platelet-suspension immunofluorescence. A drugdependent antileukocyte antibody was demonstrated by leukoagglutination and by granulocyte immunofluorescence. Both antibodies w...
متن کاملImmune hemolytic anemia and thrombocytopenia secondary to quinidine: in vitro studies of the quinidine-dependent red cell and platelet antibodies.
A patient developed immune hemolysis and thrombocytopenia while receiving quinidine. In vitro testing showed that antiquinidine antibodies of the lgG class were active against both cell lines. Complementand drug-dependent platelet lysis occurred with either the patient’s serum or his lgG fraction; there was no reaction with his 1gM fraction. Drug-dependent red cell antibodies were studied by an...
متن کاملFusidic acid-induced leukopenia and thrombocytopenia.
Fusidic acid is an active agent against a wide variety of gram-positive bacteria, and it has been increasingly used in methicillin-resistant Staphylococcus aureus infection. The major adverse effects are mild gastrointestinal discomfort and diarrhea. The hematological side effects such as granulocytopenia and thrombocytopenia have been rarely reported in western countries, but have not been doc...
متن کاملObservations on the thrombocytopenia due to hypersensitivity to quinidine.
LTHOUGH a number of instaisces of thrombocytopenia due to drugs have been reported, relatively little evidetsce is available to establish the precise role of the drug in the process and the mechanism involved. The development of a severe thrombocytopenia with hemorrhagic manifestations in a patient who had been taking quinidine, afforded an opportunity to study the causal relationship of the dr...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 1981
ISSN: 0160-9289
DOI: 10.1002/clc.4960040507